Tylenol, Motrin, Advil, Aleve all are common over the counter pain relievers. So, what separates these medications and when should you use which? 

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Motrin, Advil and Aleve are all in the same class of medication called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) which work in a similar manner to target pain relief. 

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These medications work by blocking an enzyme in the body that is used to create pain and inflammation. Tylenol on the other hand is a different class of medication that works slightly different. 

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Because these medications work differently it is important to know when you should be using one over the other.

For those who have high blood pressure, are on blood thinners, and/or have kidney disease, they should avoid the use of Motrin, Advil and Aleve as they can worsen these conditions.

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These medications act on the kidneys and cause an increase in blood pressure. They also can interact with high blood pressure medications such as lisinopril, enalapril, and losartan, and blood thinners to cause further damage to the kidneys and increased bleeding. 

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For these individuals Tylenol is the best option for pain relief. Tylenol comes in Regular Strength (325mg) Extra Strength (400mg) and Extended Release (650mg) and 325-650mg can be taken by mouth every 4 to 6 hours as needed for pain.

Do not exceed more than 4,000 mg of Tylenol in a 24 hour period. Closely read the drug label on the packaging of other over the counter products such as cough and cold relief and other combination medicines, as it may contain one of these medications. 

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It is important to not exceed the maximum daily dose and take the appropriate medication for you. If you are unsure, you can always ask the pharmacist at any of our Moose locations.

Tylenol should mainly be avoided in those who have severe liver disease. For these individuals an NSAID would be a better option. These can cause an upset stomach, so taking with food can help reduce this side effect.

Next time you find yourself in the aisle of Moose Pharmacy looking for a pain reliever, think about what other medications you are taking, what conditions you have, and whether one would be more beneficial than the other. Your kidney, liver, and blood vessels will thank you!

(It is important to note that all of these medications should not be used daily and if you find yourself needing to use them regularly, you should consult your primary care provider.)

Bullet Points:

• For those who have high blood pressure, are on blood thinners, and/or have kidney disease, they should avoid the use of Motrin, Advil and Aleve as they can worsen these conditions.
• Tylenol should mainly be avoided in those who have severe liver disease.
• Always read the label of over the counter medication to see if it contains ibuprofen or acetaminophen and what that could mean for your health.

References:

• “NSAIDs: When to Use Them and for How Long.” Cleveland Clinic, my.clevelandclinic.org/health/drugs/11086-non-steroidal-anti-inflammatory-medicines-nsaids. Accessed 2 Aug. 2023.
• “What Is Acetaminophen: Uses, Precautions, How It Works, and More.” TYLENOL®, www.tylenol.com/safety-dosing/usage/what-is-acetaminophen. Accessed 2 Aug. 2023.